Article
DNA polymerase delta is required for early mammalian embryogenesis.
PloS one - 1 Jan 2009
Uchimura Arikuni, Hidaka Yuko, Hirabayashi Takahiro, Hirabayashi Masumi, Yagi Takeshi
Abstract excerpt
BACKGROUND: In eukaryotic cells, DNA polymerase delta (Poldelta), whose catalytic subunit p125 is encoded in the Pold1 gene, plays a central role in chromosomal DNA replication, repair, and recombination. However, the physiological role of the Poldelta in mammalian development has not been thoroughly investigated. METHODOLOGY/PRINCIPAL FINDINGS: To examine this role, we used a gene targeting strategy to generate...
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