Article
Constitutive and regulated expression of the mouse Dinb (Polkappa) gene encoding DNA polymerase kappa.
DNA repair - 2 Jan 2003
Velasco-Miguel Susana, Richardson James A, Gerlach Valerie L, Lai Wayne C, Gao Tianshu, Russell Lonnie D, Hladik Christa L, White Charles L, Friedberg Errol C
Abstract excerpt
A recently discovered group of novel polymerases are characterized by significantly reduced fidelity of DNA synthesis in vitro. This feature is consistent with the relaxed fidelity required for the replicative bypass of various types of base damage that frequently block high fidelity replicative polymerases. The present studies demonstrate that the specialized DNA polymerase kappa (polkappa) is uniquely and...
Topics
- Adrenal Cortex
- Animals
- DNA Damage
- DNA-Directed DNA Polymerase
- Gene Expression Regulation
- Humans
- In Vitro Techniques
- Male
- Mice
- Mice, Transgenic
- Mutation
- Organ Specificity
- Testis
- Tumor Suppressor Protein p53