Article
DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice.
Proceedings of the National Academy of Sciences of the United States of America - 6 Oct 2009
Albertson Tina M, Ogawa Masanori, Bugni James M, Hays Laura E, Chen Yang, Wang Yanping, Treuting Piper M, Heddle John A, Goldsby Robert E, Preston Bradley D
Abstract excerpt
Organisms require faithful DNA replication to avoid deleterious mutations. In yeast, replicative leading- and lagging-strand DNA polymerases (Pols epsilon and delta, respectively) have intrinsic proofreading exonucleases that cooperate with each other and mismatch repair to limit spontaneous mutation to less than 1 per genome per cell division. The relationship of these pathways in mammals and their functions in...
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