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Mouse models of DNA polymerases.

Environmental and molecular mutagenesis - 1 Dec 2012

Menezes Miriam R, Sweasy Joann B

Abstract excerpt

In 1956, Arthur Kornberg discovered the mechanism of the biological synthesis of DNA and was awarded the Nobel Prize in Physiology or Medicine in 1959 for this contribution, which included the isolation and characterization of Escherichia coli DNA polymerase I. Now there are 15 known DNA polymerases in mammalian cells that belong to four different families. These DNA polymerases function in many different...

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PMID: 23001998
DOI: 10.1002/em.21731

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