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Article

Interdisciplinary Study of the Effects of Dipeptidyl-Peptidase III Cancer Mutations on the KEAP1-NRF2 Signaling Pathway.

International journal of molecular sciences - 11 Feb 2022

Matić Sara, Tomašić Paić Ana, Sobočanec Sandra, Pinterić Marija, Pipalović Goran, Martinčić Monika, Matovina Mihaela, Tomić Sanja

Abstract excerpt

Dipeptidyl peptidase III (DPP III) is associated with cancer progression via interaction with KEAP1, leading to upregulation of the KEAP1-NRF2 oxidative stress pathway. Numerous DPP III mutations have been found in human tumor genomes, and it is suggested that some of them may alter affinity for KEAP1. One such example is the DPP III-R623W variant, which in our previous study showed much higher affinity for the...

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Identifiers

PMID: 35216111
DOI: 10.3390/ijms23041994
PMCID: PMC8878202

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Interdisciplinary Study of the Effects of Dipeptidyl-Peptidase III Cancer Mutations on the KEAP1-NRF2 Signaling Pathway.PMID 35216111Read ↗

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