Article
Characterization of mutant strains producing pertussis toxin cross reacting materials.
Developments in biological standardization - 1 Jan 1991
Sato Y, Sato H, Chazono M, Ginnaga A, Tamura C
Abstract excerpt
We have isolated 120 mutant strains producing pertussis toxin (PT) cross reacting materials (CRMs) from B. pertussis, strain Tohama, phase I by nitrosoguanidine treatment. Strains producing higher PT tend to show higher virulence in mice. No direct correlation between the virulence and other factors, such as filamentous hemagglutinin, adenylate cyclase or dermonecrotic heat labile toxin, was found. Most CRMs were...
Topics
- Adenylate Cyclase Toxin
- Animals
- Antigens, Bacterial
- Base Sequence
- Bordetella pertussis
- Cross Reactions
- DNA, Bacterial
- Female
- Mice
- Molecular Sequence Data
- Molecular Weight