Article
Attenuated endocytosis and toxicity of a mutant cholera toxin with decreased ability to cluster ganglioside GM1 molecules.
Infection and immunity - 1 Apr 2008
Wolf Anne A, Jobling Michael G, Saslowsky David E, Kern Eli, Drake Kimberly R, Kenworthy Anne K, Holmes Randall K, Lencer Wayne I
Abstract excerpt
Cholera toxin (CT) moves from the plasma membrane (PM) of host cells to the endoplasmic reticulum (ER) by binding to the lipid raft ganglioside GM(1). The homopentomeric B-subunit of the toxin can bind up to five GM(1) molecules at once. Here, we examined the role of polyvalent binding of GM(1) in CT action by producing chimeric CTs that had B-subunits with only one or two normal binding pockets for GM(1). The...
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