Protective immunogenicity of two synthetic peptides selected from the amino acid sequence of Bordetella pertussis toxin subunit S1.

doi:10.1073/pnas.87.4.1347

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Article

Protective immunogenicity of two synthetic peptides selected from the amino acid sequence of Bordetella pertussis toxin subunit S1.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990

Askelöf P, Rodmalm K, Wrangsell G, Larsson U, Svenson S B, Cowell J L, Undén A, Bartfai T

Abstract excerpt

Two peptides, corresponding to amino acids 1-17 and 169-186 of the amino acid sequence of pertussis toxin (PT) subunit S1, were synthesized and coupled to the diphtheria toxin cross-reactive mutant protein CRM 197 and evaluated for immunogenicity and protective capacity against PT challenge in vivo. The peptide-CRM conjugates induced high antibody titers against native toxin in mice (BALB/c, C57/Black, and...

Topics

Amino Acid Sequence
Animals
Antibodies, Bacterial
Antibody Formation
Diphtheria Toxin
Enzyme-Linked Immunosorbent Assay
Immunization
Macromolecular Substances
Mice
Mice, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

NAD

Peptides

Pertussis Toxin

Virulence Factors, Bordetella

Whooping Cough

Source

Open in PubMed Open full text

Identifiers

PMID: 2304902
DOI: 10.1073/pnas.87.4.1347
PMCID: PMC53472

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2304902-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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