Article
Biochemical and biological characteristics of cross-reacting material 197 CRM197, a non-toxic mutant of diphtheria toxin: use as a conjugation protein in vaccines and other potential clinical applications.
Biologicals : journal of the International Association of Biological Standardization - 1 Jul 2011
Bröker Michael, Costantino Paolo, DeTora Lisa, McIntosh E David, Rappuoli Rino
Abstract excerpt
The biochemical and biological characteristics of CRM(197) are reviewed. Polysaccharide protein conjugate vaccines represent an important technological advancement that allowed for protection against dangerous diseases in vulnerable populations such as infants. The first carrier proteins, diphtheria and tetanus toxoids, were chosen in the context of an extensive body of information describing their immunogenicity...
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