Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Properties of pertussis toxin mutant PT-9K/129G after formaldehyde treatment.

Infection and immunity - 1 Feb 1991

Nencioni L, Volpini G, Peppoloni S, Bugnoli M, De Magistris T, Marsili I, Rappuoli R

Abstract excerpt

Formaldehyde treatment is a method routinely used to detoxify diphtheria, tetanus, and pertussis toxins as well as other molecules suitable for vaccine production. To investigate whether chemical detoxification alters the immunological properties of vaccine components, we have treated the pertussis toxin mutant PT-9K/129G with formaldehyde and tested the properties of the resulting molecules. Very low...

Topics

Animals
Bacterial Vaccines
Epitopes
Formaldehyde
Guinea Pigs
Male
Mice
Mutation
Pertussis Toxin
Virulence Factors, Bordetella

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 1702767
DOI: 10.1128/iai.59.2.625-630.1991
PMCID: PMC257803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1702767-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Properties of pertussis toxin mutant PT-9K/129G after formaldehyde treatment.PMID 1702767Read ↗

Metabolic, humoral, and cellular responses in adult volunteers immunized with the genetically inactivated pertussis toxin mutant PT-9K/129G.Semantic proximity Read ↗

Recombinant acellular pertussis vaccine--from the laboratory to the clinic: improving the quality of the immune response.Semantic proximity Read ↗

Engineering of genetically detoxified pertussis toxin analogs for development of a recombinant whooping cough vaccine.Semantic proximity Read ↗

Characterization of mutant strains producing pertussis toxin cross reacting materials.Semantic proximity Read ↗

Genetically derived toxoids for use as vaccines and adjuvants.Semantic proximity Read ↗

Double mutant and formaldehyde inactivated TSST-1 as vaccine candidates for TSST-1-induced toxic shock syndrome.Semantic proximity Read ↗

Construction of Bordetella pertussis strains that overproduce genetically inactivated pertussis toxin.Semantic proximity Read ↗

Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicitySemantic proximity Read ↗

Immunogenicity of a New Enhanced Tetanus-reduced Dose Diphtheria-acellular Pertussis (Tdap) Vaccine Against Bordetella Pertussis in a Murine ModelSemantic proximity Read ↗

The diphtheria and pertussis components of diphtheria-tetanus toxoids-pertussis vaccine should be genetically inactivated mutant toxins.Semantic proximity Read ↗

Biochemical and biological characteristics of cross-reacting material 197 CRM197, a non-toxic mutant of diphtheria toxin: use as a conjugation protein in vaccines and other potential clinical applications.Semantic proximity Read ↗

Acellular and "low" pertussis vaccines: adverse events and the role of mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.