Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of association between common polymorphisms in UGT1A9 and gene expression and activity.

Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2007

Ramírez Jacqueline, Liu Wanqing, Mirkov Snezana, Desai Apurva A, Chen Peixian, Das Soma, Innocenti Federico, Ratain Mark J

Abstract excerpt

Interindividual variability in the glucuronidation of xenobiotics metabolized by UDP-glucuronosyltransferase 1A9 (UGT1A9) suggests the presence of functional UGT1A9 variants. The aim of this study was to evaluate whether the putative functionality of the UGT1A9 variants-118T(9>10) (rs3832043), I399C>T (rs2741049), -275T>A (rs6714486), and-2152C>T (rs17868320) could be confirmed in an independent study. UGT1A9...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Flavonoids
Share to Gene Expression Regulation, Enzymologic
Share to Glucuronides
Share to Glucuronosyltransferase
Share to Luciferases, Firefly
Share to Mycophenolic Acid
Share to Piperidines
Share to UDP-Glucuronosyltransferase 1A9

Source

Identifiers

PMID: 17761781
DOI: 10.1124/dmd.107.015446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of association between common polymorphisms in UGT1A9 and gene expression and activity.PMID 17761781Read ↗

Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.Semantic proximity Read ↗

Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3.Semantic proximity Read ↗

Haplotypes of variants in the UDP-glucuronosyltransferase1A9 and 1A1 genesSemantic proximity Read ↗

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation.Semantic proximity Read ↗

The Impact of UGT1A1 Genetic Variability on Enzyme Expression in Liver Pathology.Semantic proximity Read ↗

Functional characterization of low-prevalence missense polymorphisms in the UDP-glucuronosyltransferase 1A9 gene.Semantic proximity Read ↗

Prevalence of UGT1A9 and UGT2B7 nonsynonymous single nucleotide polymorphisms in West African, Papua New Guinean, and North American populations.Semantic proximity Read ↗

Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes.Semantic proximity Read ↗

Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups.Semantic proximity Read ↗

Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs.Semantic proximity Read ↗

CYP2C9 promoter region single-nucleotide polymorphisms linked to the R150H polymorphism are functional suggesting their role in CYP2C9*8-mediated effects.Semantic proximity Read ↗

A novel polymorphism in the promoter region of human UGT1A9 gene (UGT1A9*22) and its effects on the transcriptional activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.