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Article

Haplotypes of variants in the UDP-glucuronosyltransferase1A9 and 1A1 genes

1 May 2005

Abstract excerpt

OBJECTIVES: Nine different functional UGT1A enzymes are generated from a single UGT1A gene by alternative splicing, with each enzyme having a unique exon 1. SN-38, the active metabolite of the anticancer agent irinotecan, is metabolized by both UGT1A1 and UGT1A9. We aim to characterize the UGT1A9-UGT1A1 haplotypes in Asians and Caucasians and gain insights on their functional consequences. METHODS: Asian and...

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PMID: 15864130
DOI: 10.1097/01213011-200505000-00004

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