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Article

Limited influence of UGT1A128 and no effect of UGT2B72 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes.

British journal of clinical pharmacology - 1 Oct 2007

Peterkin Vincent C, Bauman Jonathan N, Goosen Theunis C, Menning Lee, Man Michael Z, Paulauskis Joseph D, Williams J Andrew, Myrand Scott P

Abstract excerpt

AIMS: UGT1A1 and UGT2B7 are enzymes that commonly contribute to drug glucuronidation. Since genetic factors have been suggested to contribute to variability in activities and expression levels of these enzymes, a quantitative assessment of the influence of the major genotypes (UGT1A1*28 or UGT2B7*2) on enzyme activities was conducted. METHODS: Using a bank of microsomal samples from 59 human livers, the effect of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17555467
DOI: 10.1111/j.1365-2125.2007.02923.x
PMCID: PMC2048551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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