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Article

Functional characterization of low-prevalence missense polymorphisms in the UDP-glucuronosyltransferase 1A9 gene.

Drug metabolism and disposition: the biological fate of chemicals - 1 Oct 2009

Olson Kristine C, Dellinger Ryan W, Zhong Qing, Sun Dongxiao, Amin Shantu, Spratt Thomas E, Lazarus Philip

Abstract excerpt

The UDP-glucuronosyltransferase (UGT) 1A9 has been shown to play an important role in the detoxification of several carcinogens and clearance of anticancer and pain medications. The goal of the present study was to identify novel polymorphisms in UGT1A9 and characterize their effect on glucuronidation activity. The UGT1A9 gene was analyzed by direct sequencing of buccal cell genomic DNA from 90 healthy subjects....

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Identifiers

PMID: 19589876
DOI: 10.1124/dmd.108.024596
PMCID: PMC2769039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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