Article
Hoxa9/hoxb3/hoxb4 compound null mice display severe hematopoietic defects.
Experimental hematology - 1 Sept 2007
Magnusson Mattias, Brun Ann C M, Lawrence H Jeffrey, Karlsson Stefan
Abstract excerpt
OBJECTIVE: Members of the hox family of homeodomain-containing transcription factors, including hoxa9, hoxb3, and hoxb4 play an important role in the regulation of differentiation, proliferation and self-renewal of hematopoietic stem and progenitor cells. Lack-of-function studies using hoxa9, hoxb4, or hoxb3/hoxb4 null mice demonstrate that all these mutations compromise the repopulating ability of hematopoietic...
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