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Article

Molecular interactions involved in HOXB4-induced activation of HSC self-renewal.

Blood - 15 Oct 2004

Beslu Nathalie, Krosl Jana, Laurin Mélanie, Mayotte Nadine, Humphries Keith R, Sauvageau Guy

Abstract excerpt

HOXB4 overexpression induces unique in vivo and in vitro expansion of hemopoietic stem cells (HSCs) without causing leukemia. Very little is known about the molecular basis underlying HOXB4-induced HSC self-renewal. We now report the in vitro proliferation and in vivo expansion capacity of primary bone marrow (BM) cells engineered to overexpress selected HOXB4 point mutants lacking either the capacity to directly...

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Source

Identifiers

PMID: 15226173
DOI: 10.1182/blood-2004-04-1653

Genes

HOXB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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