Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae.

doi:10.1016/s0925-4773(98)00126-9

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Article

Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae.

Mechanisms of development - 1 Sept 1998

Chen F, Greer J, Capecchi M R

Abstract excerpt

Mice were generated with targeted disruptions in Hoxa7 and Hoxb7, respectively. Mice carrying the Hoxa7 mutation are healthy. No abnormalities in the formation of the skeleton or other tissues were found in these mutants. Twelve percent of Hoxb7-/- mutants show first and second rib defects simila...

Topics

Animals
Body Patterning
Bone Development
Female
Histocytochemistry
Homeodomain Proteins
Immunohistochemistry
Male
Mice
Mice, Knockout
Mutation
Neoplasm Proteins
Ribs
Spine
Stem Cells
Thoracic Vertebrae

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