Article
Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning.
Development (Cambridge, England) - 1 Mar 1998
Studer M, Gavalas A, Marshall H, Ariza-McNaughton L, Rijli F M, Chambon P, Krumlauf R
Abstract excerpt
In the developing vertebrate hindbrain Hoxa1 and Hoxb1 play important roles in patterning segmental units (rhombomeres). In this study, genetic analysis of double mutants demonstrates that both Hoxa1 and Hoxb1 participate in the establishment and maintenance of Hoxb1 expression in rhombomere 4 through auto- and para-regulatory interactions. The generation of a targeted mutation in a Hoxb1 3' retinoic acid...
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