Article
Gradual Rarefaction of Hematopoietic Precursors and Atrophy in a Depleted microRNA 29a, b and c Environment.
PloS one - 1 Jan 2015
Kauffman Lauren, Balatti Veronica, Cascione Luciano, Fadda Paolo, Racke Frederick, Santhanam Ramasamy, Costinean Stefan
Abstract excerpt
BACKGROUND: The self-renewing ability of HSCs is fundamental for the maintenance of a pool of bone marrow precursors throughout the life of an individual. The genetic mechanisms underlying such a complex process are still poorly understood. RESULTS AND SIGNIFICANCE: Here, we show that constitutive in vivo deletion of miR29ab1 leads to reduced number of HSCs and that miR29ab1 deficient bone marrow cannot...
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