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Article

HOXB4 enforces equivalent fates of ES-cell-derived and adult hematopoietic cells

10 Aug 2005

Abstract excerpt

Genetic manipulation of hematopoietic stem and progenitor cells is an important tool for experimental and clinical applied hematology. However, techniques that allow for gene targeting, subsequent in vitro selection, and expansion of genetically defined clones are available only for ES cells. Such molecularly defined and, hence, "safe" clones would be highly desirable for somatic gene therapy. Here, we...

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PMID: 16093308
DOI: 10.1073/pnas.0505624102

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