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Article

The Role of <i>HOX</i> Homeobox Genes in Normal and Leukemic Hematopoiesis

1 May 1996

Abstract excerpt

A sizable amount of new data points to a role for the HOX family of homeobox genes in hematopoiesis. Recent studies have demonstrated that HOXA and HOXB genes are expressed in human CD34+ cells, and are downregulated as cells leave the CD34+ compartment. In addition, expression of certain genes, including HOXB3 and HOXB4, is largely restricted to the long-term culture-initiating cell enriched pool, containing the...

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PMID: 8724694
DOI: 10.1002/stem.140281

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