High frequency of the HLA-DRB1*0405-(Dw15)-DQw8 haplotype in Spaniards and its relationship to diabetes susceptibility.

doi:10.1016/0198-8859(91)90053-c

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Article

High frequency of the HLA-DRB1*0405-(Dw15)-DQw8 haplotype in Spaniards and its relationship to diabetes susceptibility.

Human immunology - 1 Nov 1991

Morales P, Martinez-Laso J, Martin-Villa J M, Corell A, Vicario J L, Varela P, Pérez-Aciego P, Arnaiz-Villena A

Abstract excerpt

A study of DR4 subtypes has been done in Spanish unrelated controls and insulin-dependent diabetics by using dot blot hybridization with specific DR4B1 exon-2 oligonucleotides and automated dideoxy DNA sequencing. Dw15-DQw8 is the predominant DR4 subtype present in our normal population (37%); th...

Topics

Amino Acid Sequence
Base Sequence
DNA
Diabetes Mellitus, Type 1
Exons
Gene Frequency
Genetic Predisposition to Disease
HLA-DQ Antigens
HLA-DR Antigens
HLA-DR Serological Subtypes
HLA-DRB1 Chains
Haplotypes
Histocompatibility Antigens Class II
Humans

Source

Open in PubMed

Identifiers

PMID: 1774197
DOI: 10.1016/0198-8859(91)90053-c

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1774197-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Immunoblotting

Molecular Sequence Data

Oligonucleotide Probes

Phenotype