Article
Prognostic significance of p53 gene mutations and protein overexpression in localized gastrointestinal stromal tumours.
Histopathology - 1 Sept 2007
Ryu M H, Kang Y K, Jang S J, Kim T W, Lee H, Kim J S, Park Y H, Lee S S, Ryoo B Y, Chang H M, Lee J L, Yook J H, Kim B S, Lee J S
Abstract excerpt
AIMS: Mutation of c-kit is a relatively early event in the tumorigenesis of gastrointestinal stromal tumours (GISTs). The aim was to determine the prognostic significance of p53 alterations as an additional genetic change in GISTs. METHODS AND RESULTS: We reviewed 125 patients with localized GISTs subjected to complete resection between 1990 and 2002. Mutational analyses of c-kit exons 9, 11, 13 and 17, p53 exons...
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