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Article

Impact of KIT and PDGFRA gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resection.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract - 1 Sept 2009

Hou Ying-Yong, Grabellus Florian, Weber Frank, Zhou Yang, Tan Yun-Shan, Li Jun, Shen Kun-Tang, Qin Jin, Sun Yi-Hong, Qin Xin-Yu, Bockhorn Maximillian, Gerken Guido, Broelsch Christoph E, Frilling Andrea

Abstract excerpt

INTRODUCTION: To investigate the impact of KIT and PDGFRA gene mutations on the prognosis of gastrointestinal stromal tumors (GIST). MATERIAL AND METHODS: Tumor tissue from 184 patients with primary GIST was submitted to mutational analysis of exons 9, 11, 13, and 17 of the KIT gene and exons 12 and 18 of the PDGFRA gene. Clinical and pathological parameters were analyzed and correlated to the risk of recurrence...

Topics

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Biopsy, Needle
Disease-Free Survival
Gastrointestinal Stromal Tumors
Neoplasm Recurrence, Local

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proportional Hazards Models

Proto-Oncogene Proteins c-kit

Receptor, Platelet-Derived Growth Factor alpha

Source

Identifiers

PMID: 19291337
DOI: 10.1007/s11605-009-0842-6

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Impact of KIT and PDGFRA gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resection.PMID 19291337Read ↗

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