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Article

Gastrointestinal stromal tumors: clinical significance of p53 expression, MDM2 amplification, and KIT mutation status.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Jul 2013

Wallander Michelle L, Layfield Lester J, Tripp Sheryl R, Schmidt Robert L

Abstract excerpt

BACKGROUND: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. Clinical behavior is best predicted by size and mitotic count (risk index). KIT and platelet-derived growth factor receptor α (PDGFRA) mutations have therapeutic and prognostic value but few other prognostically significant molecular markers have been identified. We investigated the prognostic...

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Share to Gastrointestinal Stromal Tumors
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunohistochemistry

Share to In Situ Hybridization, Fluorescence

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Share to Proto-Oncogene Proteins c-kit

Share to Proto-Oncogene Proteins c-mdm2

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 23060298
DOI: 10.1097/PAI.0b013e31826ea7c0

Genes

MDM2
KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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