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Article

Prognostic significance of c-kit mutation in localized gastrointestinal stromal tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2004

Kim Tae Won, Lee Hyoungnam, Kang Yoon-Koo, Choe Mi Sun, Ryu Min-Hee, Chang Heung Moon, Kim Jung Sun, Yook Jeong Hwan, Kim Byung Sik, Lee Jung Shin

Abstract excerpt

PURPOSE: Constitutive mutational activation of c-kit has been found to be associated with the pathogenesis of gastrointestinal stromal tumors (GISTs). The prognostic significance of c-kit mutations, however, is still controversial. EXPERIMENTAL DESIGN: We examined 86 patients curatively resected for localized GIST. Genomic DNA was extracted from paraffin-embedded tumor tissues. Exons 9, 11, 13, and 17 of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Neoplasms

Share to Polymorphism, Single-Stranded Conformational

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Share to Proto-Oncogene Proteins c-kit

Share to Sequence Homology, Amino Acid

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Source

Identifiers

PMID: 15131046
DOI: 10.1158/1078-0432.ccr-03-0581

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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