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Article

Inactivating Mutations of RB1 and TP53 Correlate With Sarcomatous Histomorphology and Metastasis/Recurrence in Gastrointestinal Stromal Tumors.

American journal of clinical pathology - 1 Dec 2016

Merten Larissa, Agaimy Abbas, Moskalev Evgeny A, Giedl Johannes, Kayser Claudia, Geddert Helene, Schaefer Inga-Marie, Cameron Silke, Werner Martin, Ströbel Philip, Hartmann Arndt, Haller Florian

Abstract excerpt

OBJECTIVES: Loss-of-function mutations in TP53 and CDKN2A have been found at varying frequencies in gastrointestinal stromal tumors (GISTs), while no mutations of RB1 have been reported to date. The aim of the current study was to determine the mutation frequency of TP53, RB1, and CDKN2A in GISTs. METHODS: A cohort of 83 primary untreated GISTs was analyzed for mutations in TP53, RB1, and CDKN2A by massive...

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Share to Gastrointestinal Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Neoplasm Metastasis

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Source

Identifiers

PMID: 28028119
DOI: 10.1093/ajcp/aqw193

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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