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Article

Genetic changes in the evolution of multidrug resistance for cultured human ovarian cancer cells.

Genes, chromosomes & cancer - 1 Dec 2007

Buys Timon P H, Chari Raj, Lee Eric H L, Zhang May, MacAulay Calum, Lam Stephen, Lam Wan L, Ling Victor

Abstract excerpt

The multidrug resistant (MDR) phenotype is often attributed to the activity of ATP-binding cassette (ABC) transporters such as P-glycoprotein (ABCB1). Previous work has suggested that modulation of MDR may not necessarily be a single gene trait. To identify factors that contribute to the emergence of MDR, we undertook integrative genomics analysis of the ovarian carcinoma cell line SKOV3 and a series of MDR...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple

Share to Drug Resistance, Neoplasm

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Source

Identifiers

PMID: 17726699
DOI: 10.1002/gcc.20492

Genes

ABCB1
ABCC1
ABCC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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