Article
Cytogenetic evolution of human ovarian cell lines associated with chemoresistance and loss of tumorigenicity.
Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology - 1 Jan 2003
Struski Stéphanie, Doco-Fenzy Martine, Koehler Michael, Chudoba Ilse, Levy Francis, Masson Linda, Michel Nicole, Ulrich Evelyne, Gruson Nadine, Bénard Jean, Potron Gérard, Cornillet-Lefebvre Pascale
Abstract excerpt
In order to identify genomic changes associated with a resistant phenotype acquisition, we used comparative genomic hybridization (CGH) to compare a human ovarian cell line, Igrov1, and four derived subcell lines, resistant to vincristine and presenting a reversion of malignant properties. Multicolor FISH (Multiplex-FISH and Spectral Karyotype) and conventional FISH are also used to elucidate the karyotype of...
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