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Article

Genomic and epigenomic evolution of acquired resistance to combination therapy in esophageal squamous cell carcinoma.

JCI insight - 8 Sept 2021

Min Qingjie, Wang Yan, Wu Qingnan, Li Xianfeng, Teng Huajing, Fan Jiawen, Cao Yiren, Fan Pingsheng, Zhan Qimin

Abstract excerpt

BACKGROUNDTargeted arterial infusion of verapamil combined with chemotherapy (TVCC) is an effective clinical interventional therapy for esophageal squamous cell carcinoma (ESCC), but multidrug resistance (MDR) remains the major cause of relapse or poor prognosis, and the underlying molecular mechanisms of MDR, temporal intratumoral heterogeneity, and clonal evolutionary processes of resistance have not been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34494553
DOI: 10.1172/jci.insight.150203
PMCID: PMC8492345

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