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Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma

28 Jun 2010

Abstract excerpt

Resistance to chemotherapy in ovarian cancer is poorly understood. Evolutionary models of cancer predict that, following treatment, resistance emerges either because of outgrowth of an intrinsically resistant sub-clone or evolves in residual disease under the selective pressure of treatment. To investigate genetic evolution in high-grade serous (HGS) ovarian cancers, we first analysed cell line series derived...

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PMID: 20581869
DOI: 10.1038/onc.2010.245

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