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Article

Extended passaging of the SKOV3 ovarian cancer cell line leads to two phenotypically different strains.

Disease models & mechanisms - 1 Aug 2025

Žymantaitė Eglė, Gabrielaite Migle, Pašukonienė Vita, Mlynska Agata

Abstract excerpt

Continuous passaging of cancer cell lines can drive phenotypic and genotypic divergence, potentially compromising the reliability of such models. In this study, we show that two late-passage strains (S1 and S2) of ovarian cancer cell line SKOV3, although authenticated via short tandem repeat (STR) profiling as identical, exhibit substantial differences in morphology, transcriptomic signatures, ability to form 3D...

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Identifiers

PMID: 40755138
DOI: 10.1242/dmm.052451
PMCID: PMC12421797

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MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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