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Article

P-STAT1 mediates higher-order chromatin remodelling of the human MHC in response to IFNγ

29 Aug 2007

Abstract excerpt

Transcriptional activation of the major histocompatibility complex (MHC) by IFNgamma is a key step in cell-mediated immunity. At an early stage of IFNgamma induction, chromatin carrying the entire MHC locus loops out from the chromosome 6 territory. We show here that JAK/STAT signalling triggers this higher-order chromatin remodelling and the entire MHC locus becomes decondensed prior to transcriptional...

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PMID: 17726060
DOI: 10.1242/jcs.012328

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