Article
A genetic variant controls interferon-β gene expression in human myeloid cells by preventing C/EBP-β binding on a conserved enhancer.
PLoS genetics - 1 Nov 2020
Assouvie Anaïs, Rotival Maxime, Hamroune Juliette, Busso Didier, Romeo Paul-Henri, Quintana-Murci Lluis, Rousselet Germain
Abstract excerpt
Interferon β (IFN-β) is a cytokine that induces a global antiviral proteome, and regulates the adaptive immune response to infections and tumors. Its effects strongly depend on its level and timing of expression. Therefore, the transcription of its coding gene IFNB1 is strictly controlled. We have previously shown that in mice, the TRIM33 protein restrains Ifnb1 transcription in activated myeloid cells through an...
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