Article
STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2015
Wagatsuma Keisuke, Tani-ichi Shizue, Liang Bingfei, Shitara Soichiro, Ishihara Ko, Abe Manabu, Miyachi Hitoshi, Kitano Satsuki, Hara Takahiro, Nanno Masanobu, Ishikawa Hiromichi, Sakimura Kenji, Nakao Mitsuyoshi, Kimura Hiroshi, Ikuta Koichi
Abstract excerpt
The transcription factor STAT5, which is activated by IL-7R, controls chromatin accessibility and rearrangements of the TCRγ locus. Although STAT-binding motifs are conserved in Jγ promoters and Eγ enhancers, little is known about their precise roles in rearrangements of the TCRγ locus in vivo. To address this question, we established two lines of Jγ1 promoter mutant mice: one harboring a deletion in the Jγ1...
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