Article

STAT1 is required to establish but not maintain IFNγ-induced transcriptional memory

2022-09-17

Abstract excerpt

Exposure of human cells to interferon-γ (IFNγ) results in a mitotically heritable yet reversible state called long-term transcriptional memory. We previously identified the clustered GBP genes as strongly primed by IFNγ. Here we discovered that in primed cells, both interferon-responsive transcription factors STAT1 and IRF1 target chromatin with accelerated kinetics upon re-exposure to IFNγ, specifically at promot...

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Literature Corpus work: ca628b73-30a5-5cde-a836-8951411cbb11
DOI: 10.1101/2022.09.17.508285

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