Article
Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2005
Zhong Minghao, Henriksen Melissa A, Takeuchi Kenji, Schaefer Olaf, Liu Bin, ten Hoeve Johanna, Ren Zhiyong, Mao Xiang, Chen Xiaomin, Shuai Ke, Darnell James E
Abstract excerpt
IFN-gamma treatment of cells leads to tyrosine phosphorylation of signal transducer and activator of transcription (STAT) 1 followed by dimerization through a reciprocal Src homology 2-phosphotyrosine interaction near the -COOH end of each monomer, forming a parallel structure that accumulates in the nucleus to drive transcription. Prompt dephosphorylation and return to the cytoplasm completes the...
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