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Article

Roles of Smad3 in TGF-beta signaling during carcinogenesis.

Critical reviews in eukaryotic gene expression - 1 Jan 2007

Millet Caroline, Zhang Ying E

Abstract excerpt

Signaling of transforming growth factor beta (TGF-beta) is mediated through a heteromeric complex of two types of transmembrane receptors and downstream intracellular proteins known as Smads. Alterations of TGF-beta signaling underlie various forms of human cancer and developmental diseases. Human genetic studies have revealed both point mutations and deletions of Smad2 or Smad4 in several types of cancers....

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Share to Carcinoma, Hepatocellular
Share to Cell Transformation, Neoplastic
Share to Liver Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17725494
DOI: 10.1615/critreveukargeneexpr.v17.i4.30
PMCID: PMC2639747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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