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Article

Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer.

Oncogene - 19 Feb 2004

Han Sang-Uk, Kim Heung-Tae, Seong Do Hwan, Kim Yong-Suk, Park Yoon-Soo, Bang Yung-Jue, Yang Han-Kwang, Kim Seong-Jin

Abstract excerpt

Loss of the tumor suppressive effect of transforming growth factor-beta (TGF-beta) has been commonly found at later stages in carcinogenic progression. Although the genes encoding TGF-beta receptors and Smads have been found genetically altered in certain human cancers, no mutation in Smad3 has been observed. Therefore, suppression of Smad3 expression may mediate key oncogenic properties of TGF-beta. First, we...

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Identifiers

PMID: 14647420
DOI: 10.1038/sj.onc.1207259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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