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Article

The role of TGF-β/SMAD4 signaling in cancer.

International journal of biological sciences - 1 Jan 2018

Zhao Ming, Mishra Lopa, Deng Chu-Xia

Abstract excerpt

Transforming growth factor β (TGF-β) signaling pathway plays important roles in many biological processes, including cell growth, differentiation, apoptosis, migration, as well as cancer initiation and progression. SMAD4, which serves as the central mediator of TGF-β signaling, is specifically inactivated in over half of pancreatic duct adenocarcinoma, and varying degrees in many other types of cancers. In the...

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Source

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Identifiers

PMID: 29483830
DOI: 10.7150/ijbs.23230
PMCID: PMC5821033

Genes

SMAD4
APC
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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