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Article

Mechanisms of Action of TGF‐β in Cancer

1 Oct 2007

Abstract excerpt

Transforming growth factor-beta (TGF-beta) induces cell differentiation and suppresses cell proliferation, but the mechanisms underlying the actions of TGF-beta remain to be fully elucidated. Recent studies suggest that TGF-beta suppresses neoplastic cell development by employing Smad3 protein to repress the gene of human telomerase reverse transcriptase (hTERT). In human breast cancer cells, TGF-beta induces...

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PMID: 17934056
DOI: 10.1196/annals.1396.016

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