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Smad3 Protein Levels Are Modulated by Ras Activity and during the Cell Cycle to Dictate Transforming Growth Factor-β Responses

27 Dec 2009

Abstract excerpt

Transforming growth factor beta (TGF-beta) regulates many biological processes, and aberrant TGF-beta signaling is implicated in tumor development. Smad3 is a central component of the TGF-beta signaling pathway, and once activated, Smad3 forms complexes with Smad4 or other receptor-regulated Smads, which accumulate in the nucleus to transcriptionally regulate TGF-beta target genes. Because Smad3 plays a...

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PMID: 20037158
DOI: 10.1074/jbc.m109.043877

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