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Article

A Skp2 autoinduction loop and restriction point control

27 Aug 2007

Abstract excerpt

We describe a self-amplifying feedback loop that autoinduces Skp2 during G1 phase progression. This loop, which contains Skp2 itself, p27(kip1) (p27), cyclin E-cyclin dependent kinase 2, and the retinoblastoma protein, is closed through a newly identified, conserved E2F site in the Skp2 promoter. Interference with the loop, by knockin of a Skp2-resistant p27 mutant (p27(T187A)), delays passage through the...

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PMID: 17724117
DOI: 10.1083/jcb.200703034

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