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Article

Racing to block tumorigenesis after pRb loss: an innocuous point mutation wins with synthetic lethality.

Cell cycle (Georgetown, Tex.) - 1 Jun 2010

Bauzon Frederick, Zhu Liang

Abstract excerpt

A major goal of tumor suppressor research is to neutralize the tumorigenic effects of their loss. Since loss of pRb does not induce tumorigenesis in many types of cells, natural mechanisms may neutralize the tumorigenic effects of pRb loss in these cells. For susceptible cells, neutralizing the tumorigenic effects of pRb loss could logically be achieved by correcting the deregulated activities of pRb targets to...

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Identifiers

PMID: 20505340
DOI: 10.4161/cc.9.11.11726
PMCID: PMC3044209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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