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Article

Cyclin E-CDK2 is a regulator of p27Kip1.

Genes & development - 1 Jun 1997

Sheaff R J, Groudine M, Gordon M, Roberts J M, Clurman B E

Abstract excerpt

CDK inhibitors are thought to prevent cell proliferation by negatively regulating cyclin-CDK complexes. We propose that the opposite is also true, that cyclin-CDK complexes in mammmalian cells can promote cell cycle progression by directly down-regulating CDK inhibitors. We show that expression of cyclin E-CDK2 in murine fibroblasts causes phosphorylation of the CDK inhibitor p27Kip1 on T187, and that cyclin...

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Source

Identifiers

PMID: 9192873
DOI: 10.1101/gad.11.11.1464

Genes

CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Cyclin E-CDK2 is a regulator of p27Kip1.PMID 9192873Read ↗

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