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Article

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells.

Nature cell biology - 1 Aug 1999

Sutterlüty H, Chatelain E, Marti A, Wirbelauer C, Senften M, Müller U, Krek W

Abstract excerpt

The F-box protein p45SKP2 is the substrate-targeting subunit of the ubiquitin-protein ligase SCFSKP2 and is frequently overexpressed in transformed cells. Here we report that expression of p45SKP2 in untransformed fibroblasts activates DNA synthesis in cells that would otherwise growth-arrest. Expression of p45SKP2 in quiescent fibroblasts promotes p27Kip1 degradation, allows the generation of cyclin-A-dependent...

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PMID: 10559918
DOI: 10.1038/12027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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