Article
muO conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2.
Channels (Austin, Tex.) - 1 Jan 2000
Leipold Enrico, DeBie Herbert, Zorn Stefan, Borges Adolfo, Olivera Baldomero M, Terlau Heinrich, Heinemann Stefan H
Abstract excerpt
The muO-conotoxins MrVIA and MrVIB are 31-residue peptides from Conus marmoreus, belonging to the O-superfamily of conotoxins with three disulfide bridges. They have attracted attention because they are inhibitors of tetrodotoxin-insensitive voltage-gated sodium channels (Na(V)1.8) and could therefore serve as lead structure for novel analgesics. The aim of this study was to elucidate the molecular mechanism by...
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