Article
muO conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2.
Channels (Austin, Tex.) - 1 Jan 2000
Leipold Enrico, DeBie Herbert, Zorn Stefan, Borges Adolfo, Olivera Baldomero M, Terlau Heinrich, Heinemann Stefan H
Abstract excerpt
The muO-conotoxins MrVIA and MrVIB are 31-residue peptides from Conus marmoreus, belonging to the O-superfamily of conotoxins with three disulfide bridges. They have attracted attention because they are inhibitors of tetrodotoxin-insensitive voltage-gated sodium channels (Na(V)1.8) and could ther...
Topics
- Animals
- Cell Line
- Conotoxins
- Humans
- Ion Channel Gating
- Membrane Potentials
- Muscle Proteins
- Mutagenesis, Site-Directed
- Mutation
- Patch-Clamp Techniques
- Protein Conformation
- Protein Structure, Tertiary
- Rats
- Scorpion Venoms
- Sodium
- Sodium Channel Blockers
- Sodium Channels
- Transfection