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Article

Structural determinants for alpha-neurotoxin sensitivity in muscle nAChR and their implications for the gating mechanism.

Channels (Austin, Tex.) - 1 Jan 2000

Dellisanti Cosma D, Yao Yun, Stroud James C, Wang Zuo-Zhong, Chen Lin

Abstract excerpt

Neurotoxins from snake venoms act as potent antagonists on the nicotinic acetylcholine receptors (nAChRs). Alpha-neurotoxins such as alpha-bungarotoxin (alpha-Btx) selectively bind to the skeletal muscle nAChRs among other subtypes, causing failure of the neuromuscular transmission. Through evolution, some species including snakes and mongoose have developed resistance to alpha-neurotoxins via specific amino acid...

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Identifiers

PMID: 18708746
DOI: 10.4161/chan.4909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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