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Article

Batrachotoxin-resistant Na+ channels derived from point mutations in transmembrane segment D4-S6.

Biophysical journal - 1 Jun 1999

Wang S Y, Wang G K

Abstract excerpt

Local anesthetics (LAs) block voltage-gated Na+ channels in excitable cells, whereas batrachotoxin (BTX) keeps these channels open persistently. Previous work delimited the LA receptor within the D4-S6 segment of the Na+ channel alpha-subunit, whereas the putative BTX receptor was found within the D1-S6. We mutated residues at D4-S6 critical for LA binding to determine whether such mutations modulate the BTX...

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Identifiers

PMID: 10354438
DOI: 10.1016/S0006-3495(99)77465-5
PMCID: PMC1300282

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