Article
Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling.
Cell - 24 Aug 2007
Iwasato Takuji, Katoh Hironori, Nishimaru Hiroshi, Ishikawa Yukio, Inoue Haruhisa, Saito Yoshikazu M, Ando Reiko, Iwama Mizuho, Takahashi Ryosuke, Negishi Manabu, Itohara Shigeyoshi
Abstract excerpt
The ephrin/Eph system plays a central role in neuronal circuit formation; however, its downstream effectors are poorly understood. Here we show that alpha-chimerin Rac GTPase-activating protein mediates ephrinB3/EphA4 forward signaling. We discovered a spontaneous mouse mutation, miffy (mfy), which results in a rabbit-like hopping gait, impaired corticospinal axon guidance, and abnormal spinal central pattern...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.